|
Match
|
Document |
Document Title |
|
|
8114830 |
Polypeptoid pulmonary surfactants
The present invention provides spreading agents based on sequence-specific oligomers comprising a peptoid, a peptide-peptoid chimera, a retropeptoid or a retro(peptoid-peptide) chimera, and methods...
|
|
|
8105603 |
Polypeptides that bind APRIL
The present invention relates to polypeptides that inhibit APRIL and/or BAFF binding to BCMA, nucleic acid molecules encoding the polypeptides, and compositions comprising the polypeptides. The...
|
|
|
8093363 |
Tumor necrosis factor-gamma
Human TNF-gamma-alpha and TNF-gamma-beta polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques are disclosed. Also...
|
|
|
8063182 |
Human TNF receptor fusion protein
The present invention is concerned with non-soluble proteins and soluble or insoluble fragments thereof, which bind TNF, in homogeneous form, as well as their physiologically compatible salts,...
|
|
|
8063016 |
Retro-inverso peptides derived from interleukin-6
This invention provides methods of treatment using retro-inverso peptides derived from interleukin-6 (IL-6) having between 15 and about 40 amino acids, and including the sequence that is...
|
|
|
8013112 |
Compositions comprising human brain natriuretic peptide (BNP) fragments
The present invention relates among other things to a composition comprising at least two (2) human BNP fragments, wherein each of the human BNP fragments of the composition are cross-linked to at...
|
|
|
8007592 |
Plants with increased activity of a starch phosphorylating enzyme
The present invention relates to plant cells and plants, which are genetically modified, whereby the genetic modification leads to an increase in the activity of a starch-phosphorylating OK1...
|
|
|
8008440 |
Combinatorial synthesis of libraries of macrocyclic compounds useful in drug discovery
A library of macrocyclic compounds of the formula (I) where part (A) is a bivalent radical, a —(CH2)y— bivalent radical or a covalent bond;where part (B) is a bivalent radical, a —(CH2)z— bivalen...
|
|
|
7999075 |
Methods for identifying compounds that regulate beta-arrestin signaling complexes
A method of screening a candidate compound for βArrestin mediated anti-G protein coupled receptor signaling activity is comprises: (a) contacting said candidate compound to a βArrestin signaling c...
|
|
|
7960123 |
Multimarker panel based on PIGF for diabetes types 1 and 2
The present invention relates to a method and means for diagnosing or risk stratification of co-morbidities, particularly cardiovascular complications in diabetes patients. The invention...
|
|
|
7955590 |
Fc fusion proteins for enhancing the immunogenicity of protein and peptide antigens
Disclosed herein are methods and compositions for enhancing the immunogenicity of a preselected protein or peptide antigen in a mammal. Immunogenicity is enhanced by fusing the preselected antigen...
|
|
|
7951371 |
Soluble lymphotoxin-β receptor fusion protein and methods for inhibiting lymphotoxin β-receptor signaling
This invention relates to compositions and methods comprising “lymphotoxin-β-receptor blocking agents”, which block lymphotoxin-β receptor signalling. Lymphotoxin-β receptor blocking agents are us...
|
|
|
7927605 |
Environmentally regulated genes of Streptococcus suis
The invention relates to the field of the diagnosis of and vaccination against Streptococcal infections, and to the detection of virulence markers of Streptococci. The invention discloses a method...
|
|
|
7888311 |
Uranium-chelating peptides and uses thereof
The invention concerns uranium-chelating peptides as well as their uses for decontaminating soils and water, and for detecting and treating people contaminated by uranium. Said peptides have a...
|
|
|
7879577 |
Modified polypeptides stabilized in a desired conformation and methods for producing same
The present invention provides a method for stabilizing a protein in a desired conformation by introducing at least one disulfide bond into the polypeptide. Computational design is used to identify...
|
|
|
7872100 |
Nitrile hydratases from metagenome libraries
The present invention is concerned with the preparation of novel nitrile hydratases. These latter are preferably obtained from nonculturable organisms by means of a PCR-based screening, in...
|
|
|
7855175 |
Peptides that bind to the erythropoietin receptor
The present invention relates to peptide compounds that are agonists of the erythropoietin receptor (EPO-R). The invention also relates to therapeutic methods using such peptide compounds to treat...
|
|
|
7834258 |
Dimer of chimeric recombinant binding domain-functional group fusion formed via disulfide-bond-bridge and the processes for producing the same
The present invention relates to a method producing dimer of chimeric recombinant binding domain-heterogeneous functional group fusion([B-F fusion]2) by using covalent disulfide-bond-bridge...
|
|
|
7812126 |
DIRS1 polypeptides
Nucleic acids encoding mammalian, e.g., primate or rodent receptors, purified receptor proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of...
|
|
|
7807397 |
Diagnostic method for disorders using copeptin
The use of copeptin as diagnostic marker for the determination of the release of vasopressin, especially in connection with disorders associated with non-physiological alterations of vasopressin...
|
|
|
7799339 |
Hybrid block copolymer micelles with mixed stereochemistry for encapsulation of hydrophobic agents
The present invention relates to the field of polymer chemistry and more particularly to multiblock copolymers and micelles comprising the same.
|
|
|
7795399 |
Stable therapeutic proteins
The invention relates to storable medicaments produced from pharmaceutical active ingredient preparations which are virus safe. Said medicaments contain at least one intact therapeutic protein...
|
|
|
7790675 |
Method for increasing frataxin expression
Use of human erythropoietin or a derivative of erythropoietin having the biological activity of human erythropoietin of increasing the expression of frataxin for the production of a pharmaceutical...
|
|
|
7785588 |
Anti-neurturin receptor-A antibody compositions comprising cytokines or neurotrophic factors
NTNRα, NTNRα extracellular domain (ECD), NTNRα variants, chimeric NTNRα (e.g., NTNRα immunoadhesion), and antibodies which bind thereto (including agonist and neutralizing antibodies) are disc...
|
|
|
7785579 |
Modified tumor necrosis factor
Modifying TNF with polyethyleneglycol (PEG) having an approximate weight average molecular weight in the range of about 10,000 to about 40,000, preferably in the range of about 20,000 to 30,000,...
|
|
|
7763704 |
Sushi peptide multimer
Endotoxin, also known as lipopolysaccharides (LPS), is the major mediator of septic shock due to Gram-negative bacterial infection. Chemically synthesized S3 peptide, derived from Sushi3 domain of...
|
|
|
7741289 |
Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
The present invention provides compounds represented by the structural formula (I): or pharmaceutically acceptable isomers, salts, solvates or esters of the compound of Formula (I), wherein each of...
|
|
|
7732413 |
Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
The present invention provides compounds represented by the structural formula (I): or pharmaceutically acceptable isomers, salts, solvates or esters of the compound of Formula (I), wherein each of...
|
|
|
7722880 |
Immunoreactive 38-KDA ferric binding protein of ehrlichia canis and uses thereof
The present invention is directed to the cloning, sequencing, expression, and characterization of an immunoreactive ferric binding protein (Fbp) (38-kDa) protein of Ehrlichia canis encoded by a...
|
|
|
7704958 |
Methods and compositions for inhibiting apoptosis using serine protease inhibitors
The instant invention provides a method of treating an animal suffering a disease characterized by excessive apoptosis by administering a therapeutically effective amount of at least one serine...
|
|
|
7705119 |
Compositions and methods useful for treating circulatory and hypovolemic shock
Polypeptides, compositions, and methods for treating shock are described. A isolated polypeptide, Deltorphin-E, can be administered without concomitant fluid resuscitation, before, concurrently...
|
|
|
7700562 |
Use of —furin—“convertase” inhibitors in the treatment of fibrosis and scarring
The present invention relates to use of convertase inhibitors for the reduction of scarring during the healing of wounds and also for reducing fibrosis in the treatment of fibrotic conditions.
|
|
|
7674769 |
Treatment of severe pneumonia by administration of tissue factor pathway inhibitor (TFPI)
Methods for prophylactically or therapeutically treating severe pneumonia involve administration of tissue factor pathway inhibitor (TFPI) or a TFPI analog to patients suffering from or at risk of...
|
|
|
7674604 |
Modified polypeptides stabilized in a desired conformation and methods for producing same
The present invention provides a method for stabilizing a protein in a desired conformation by introducing at least one disulfide bond into the polypeptide. Computational design is used to identify...
|
|
|
7642244 |
Neuropeptide-2 receptor (Y-2R) agonists and uses thereof
Provided herein are neuropeptide-2 receptor agonists of the formula (I): as well as pharmaceutically acceptable salts, derivatives and fragments thereof, wherein the substituents are as those...
|
|
|
7632819 |
Methods and compositions for inhibiting PKC delta cleavage for treatment and prevention of neurodegeneration and apoptosis
Methods and compositions are provided which inhibit the apoptotic activity associated with oxidative stress in many disease states. According to the invention, inhibition of chemical cleavage of...
|
|
|
7605121 |
Oligopeptide lyophilisate, their preparation and use
A novel lyophilizate and method of preparation as well as the use of the lyophilizate to treat female infertility and for gonad protection. Cetrorelix is dissolved in acetic acid 30% v/v, the...
|
|
|
7597886 |
Tumor necrosis factor-gamma
Human TNF-gamma-alpha and TNF-gamma-beta polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques are disclosed. Also...
|
|
|
7585836 |
Bi-lateral local renal delivery for treating congestive heart failure and for BNP therapy
The invention relates to systems and methods for local renal delivery of agents to subjects that are at risk for congestive heart failure and other conditions. The invention encompasses devices for...
|
|
|
7569660 |
Recombinant prion-like proteins and materials comprising same
The present invention provides novel polypeptides comprising a prion-aggregation domain and a second domain; novel polynucleotides encoding such polypeptides; host cells transformed or transfected...
|
|
|
7566447 |
Biocides
The present invention relates to the use of biocide (e.g., bactericidal enzyme) to target pathogens. In particular, the present invention provides biocides for use in health care (e.g., human and...
|
|
|
7553930 |
BAFF variants and methods thereof
The invention relates to novel proteins with BAFF dominant negative antagonist, receptor antagonist activity and agonist activity and nucleic acids encoding these proteins. The invention further...
|
|
|
7544655 |
Haptotactic peptides
Novel cell attachment peptides having sequences homologous to specific portions of the carboxy terminal sequence of fibrinogen chains are disclosed. The novel peptides, derived from proteins...
|
|
|
7544662 |
Polypeptides useful for appetite suppression
The present invention relates to polypeptides obtained from bear derivative isolate which are useful in suppressing appetite. The polypeptides of the present invention are most preferably between...
|
|
|
7531522 |
Antibodies, recombinant antibodies, recombinant antibody fragments and fusions mediated plant disease resistance against fungi
A method for the production of fungus resistant transgenic plants, plant cells or plant tissue comprising the introduction of an Ab, rAb, rAb fragment or fusion or vector of the invention or the...
|
|
|
7491490 |
Cytomegalovirus disintegrin-like peptides
The present invention relates to methods and compositions for inhibiting the entry of viruses, such as herpesviruses into a host cell. A conserved viral integrin-binding gB disintegrin-like domain...
|
|
|
7485446 |
Stable retrovirus and methods of use
The present invention is a mutant retroviral protease which confers an increase in retroviral stability. Retroviruses expressing the instant mutant retroviral protease exhibit at least a 2-fold...
|
|
|
7449445 |
Conductive peptide nanofiber and method of manufacture of the same
A peptide nanofiber having conductivity is provided. A conductive peptide nanofiber which includes a nanofiber formed through a manner of self-assembly of a peptide that has a nanofiber-forming...
|
|
|
7439347 |
Hepatitis C virus non-structural NS3/4A fusion gene
Disclosed herein is the discovery of a novel hepatitis C virus (HCV) isolated from a human patient. Embodiments of the invention include HCV peptides, nucleic acids encoding said HCV peptides,...
|
|
|
7402558 |
Method for aiding implantation or decreasing miscarriage rate
The invention provides a protocol leading to improved embryo implantation rates and/or decreased miscarriage rates in which hCG or LH, or a bio-analogue thereof, is administered during the...
|