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8119608 |
Method and medicament for inhibiting the expression of a given gene
The present invention provides methods and compositions for inhibiting gene expression using double stranded RNA molecules that are between 15 and 24 nucleotides in length and are complementary to...
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8119766 |
Increasing functional glycosylation of alpha-dystroglycan in the treatment of muscle degeneration
Disclosed is a method for the prevention and/or treatment of muscle degeneration. In this method, a subject recognized as having muscle degeneration is treated with a composition effective to...
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8119791 |
si-RNA-mediated gene silencing technology to inhibit tyrosinase and reduce pigmentation
The present invention describes compositions and methods for treating, preventing and improving hyperpigmentation, or other unwanted pigmentation of the skin, or other unwanted skin condition, such...
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8119789 |
Method for the production of a cell and/or tissue and/or disease phase specific medicament
The present invention relates to a method for producing of a cell and/or tissue and/or disease phase specific medicament against against chronic inflammatory diseases. Disease, cell type, tissue...
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8119610 |
Method for efficient RNA interference in mammalian cells
The present invention relates to methods of making RNAi libraries using E. coli RNAse III for inhibition of mammalian gene expression.
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8119400 |
Methods of inhibiting smooth muscle cell migration and proliferation
In particular embodiments, the present invention provides methods of inhibiting smooth muscle cell responses and methods of treating or preventing vascular proliferative disease caused by smooth...
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8114852 |
N-linked glycosylation alteration in E1 glycoprotein of classical swine fever virus and novel classical swine fever virus vaccine
E1, along with Erns and E2 is one of the three envelope glycoproteins of Classical Swine Fever Virus (CSFV). Our previous studies indicated that glycosylation status of either E2 or Erns strongly...
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8114985 |
Anti-MicroRNA oligonucleotide molecules
The invention relates to isolated anti-microRNA molecules. In another embodiment, the invention relates to an isolated microRNA molecule. In yet another embodiment, the invention provides a method...
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8114981 |
Method and medicament for inhibiting the expression of a given gene
The invention relates to an isolated RNA that mediates RNA interference of an mRNA to which it corresponds and a method of mediating RNA interference of mRNA of a gene in a cell or organism using...
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8114982 |
Multi-microRNA methods and compositions
Provided are DNAs comprising a polynucleotide that encodes at least a first modified miR-30 precursor and a second modified miR-30 precursor. Also provided are vectors comprising the the DNAs,...
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8114984 |
RNAi modulation of Aha and therapeutic uses thereof
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of an Aha gene (Aha1 gene), comprising an antisense strand having a nucleotide sequence which is...
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8114851 |
Method and medicament for inhibiting the expression of a given gene
The present invention relates to the specific inhibition of expression of a target gene in mammals using a short double stranded RNA. The dsRNA is less than 49 nucleotides in length and has a...
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8114983 |
Compositions and use of EPAS1 inhibitors
The present invention relates to inhibitors of endothelial PAS domain protein 1 (EPAS1), and methods and compositions related to the EPAS1 inhibitors. In certain embodiments, the EPAS1 inhibitors...
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8110559 |
Hindered ester-based biodegradable linkers for oligonucleotide delivery
The invention provides hindered ester-based biodegradable linkers for the delivery of oligonucleotides in vivo, as well as method of making and using the same.
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8110674 |
Therapeutic compositions
Therapeutic sRNA agents and methods of making and using are enclosed.
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8110558 |
Oligomeric compounds and compositions for use in modulation of small non-coding RNAS
Compounds, compositions and methods are provided for modulating the expression and function of small non-coding RNAs. The compositions comprise oligomeric compounds, targeted to small non-coding...
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8110560 |
Spinal muscular atrophy (SMA) treatment via targeting of SMN2 splice site inhibitory sequences
The present invention is directed to methods and compositions capable of blocking the inhibitory effect of a newly-identified intronic inhibitory sequence element, named ISS-N1 (for “intronic s...
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8106182 |
Antisense oligonucleotides (ODN) against Smad7 and uses thereof in medical field
The invention relates to antisense oligonucleotidic sequences (ODN) against Smad7 suitably modified, and their uses in medical field as therapeutic biological agents, in particular in the treatment...
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8106027 |
Development of a preventive vaccine for filovirus infection in primates
The present invention relates generally to viral vaccines and, more specifically, to filovirus vaccines and methods of eliciting an immune response against a filovirus or disease caused by...
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8105574 |
Simian adenovirus nucleic acid and amino acid sequences, vectors containing same, and methods of use
A recombinant vector comprises simian adenovirus sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus gene(s) is also...
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8106026 |
Development of a preventive vaccine for filovirus infection in primates
The present invention relates generally to viral vaccines and, more specifically, to filovirus vaccines and methods of eliciting an immune response against a filovirus or disease caused by...
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8106028 |
MicroRNA-21 antagonists and its target PDCD4 for use in the treatment of a glioma
The present invention embraces microRNA-21 antagonists and activators of Programmed Cell Death 4 for use in decreasing glial tumor cell proliferation and treating glioma.
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8101584 |
Method and medicament for inhibiting the expression of a given gene
The present invention provides methods and compositions for inhibiting gene expression using double stranded RNA molecules that are between 15 and 21 nucleotides in length and are complementary to...
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8101742 |
Method and medicament for inhibiting the expression of a given gene
The invention relates to an isolated RNA that mediates RNA interference of an mRNA to which it corresponds and a method of mediating RNA interference of mRNA of a gene in a cell or organism using...
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8101585 |
Compositions and methods for the modulation of JNK proteins
The invention provides compositions and methods for the treatment and diagnosis of diseases or disorders amenable to treatment through modulation of expression of a gene encoding a Jun N-terminal...
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8101343 |
Delivery of dsRNA to arthropods
The invention is to methods of gene silencing in arthropods using dsRNA. The method is include contacting the arthropod with, and/or directly feeding the arthropod, the dsRNA to the arthropods to...
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8097599 |
Plasmid encoding feline BMP-7
The present invention relates to recombinant vectors expressing the BMP-7 polypeptide in host cells and to pharmaceutical compositions comprising such recombinant vectors. The invention also...
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8097715 |
Multitargeting interfering RNAs having two active strands and methods for their design and use
Interfering RNA molecules are now designed and produced with specificity for multiple binding sequences present in distinct genetic contexts in one or more pre-selected target RNA molecules and are...
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8097712 |
Compositions for conferring tolerance to viral disease in social insects, and the use thereof
Compositions and methods for reducing susceptibility to infectious disease in bees using RNA interference technology, and more particularly, prevention and treatment of viral infections in...
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8097597 |
Use of low doses of oligonucleotides antisense to TGF-β genes in the treatment of brain tumors
This invention is related to the use of at least one oligonucleotide with a length of from about 8 to about 30 nucleotide building blocks for manufacturing a pharmaceutical preparation for the...
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8097277 |
Charge-dynamic polymers and delivery of anionic compounds
The present invention provides dynamic charge state cationic polymers that are useful for delivery of anionic molecules. The dynamic charge state cationic polymers are designed to have cationic...
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8093222 |
Methods for treating hypercholesterolemia
Disclosed herein are antisense compounds and methods for decreasing LDL-C in an individual having elevated LDL-C. Additionally disclosed are antisense compounds and methods for treating,...
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8093366 |
Dbait and standalone uses thereof
The invention relates to compositions and methods for interfering with the DNA repair of double strand breaks (DSBs). The invention discloses double-stranded nucleic acid molecules that act as...
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8093221 |
Cosmetic and pharmaceutical compositions comprising lauroyl proline and an ester of anhydrohexitol and of an aliphatic carboxylic acid
Composition (A) containing, for 100% of its mass: from 10 mass % to 90 mass % of N-lauroyl proline (I) and from 10 mass % to 90 mass % of an ester (II) of anhydrohexitol and of a saturated or...
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8093223 |
RIP140 regulation of diabetes
Inhibition of RIP140 increases glucose transport. Compounds that inhibit RIP140 expression or activity are useful for treating disorders associated with aberrant glucose transport (e.g., diabetes),...
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8093043 |
β-TrCP1, β-TrCP2 and RSK1 or RSK2 inhibitors and methods for sensitizing target cells to apoptosis
The invention relates to modulating BimEL levels (Bcl-2-Interacting Mediator of cell death, Extra Long isoform) to sensitize cancer cells to cell death or apoptosis. In certain embodiments, the...
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8088914 |
MicroRNA and methods for inhibiting same
The invention relates to isolated DNA or RNA molecules comprising at least ten contiguous bases having a sequence in a pancreatic islet microRNA. In another embodiment, the invention relates to...
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8088913 |
Compositions and methods for therapy and diagnosis of cancer
The present invention is directed to siRNA molecules which specifically target and cause RNAi-induced degradation of mRNA from TPTE genes, so that the protein product of the TPTE gene is not...
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8088749 |
Compositions and methods for treating cancer
The present invention relates to therapeutic targets for cancer. In particular, the present invention relates to small molecules and nucleic acids that target ATDC (TRIM29) expression in cancer...
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8088912 |
pRNA chimera
A polyvalent multimeric complex formed from a plurality of circularly permuted chimeric pRNA molecules, each carrying a stabilized biologically active moiety.
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8084437 |
Methods for treating hypercholesterolemia
Disclosed herein are antisense compounds and methods for decreasing LDL-C in an individual having elevated LDL-C. Additionally disclosed are antisense compounds and methods for treating...
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8084435 |
Biodegradable linkers for molecular therapies
A method and a composition for delivery of a biomaterial to an animal cell or a tissue, the composition includes (a) a biomaterial; (b) a biodegradable cross-linker portion having a hydrolyzable...
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8084599 |
Methods and compositions for the specific inhibition of gene expression by double-stranded RNA
The invention is directed to compositions and methods for selectively reducing the expression of a gene product from a desired target gene in a cell, as well as for treating diseases caused by the...
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8084601 |
Oligomers
Molecules are provided for inducing or facilitating exon skipping in forming spliced mRNA products from pre-mRNA molecules in cells. The molecules may be provided directly as oligonucleotides or...
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8084433 |
Antisense antiviral compound and method for treating ssRNA viral infection
The invention provides antisense antiviral compounds and methods of their use and production in inhibition of growth of viruses of the Flaviviridae, Picomoviridae, Caliciviridae, Togaviridae,...
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8084589 |
Phosphoramidite nucleoside analogs
Described are phosphoramidite nucleoside analog monomers, precursors thereof, and oligonucleotides including one or more of the monomers. The monomers can be used during automated synthesis of...
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8080534 |
Targeting PAX2 for the treatment of breast cancer
The present application provides methods of prevention and/or treatment of breast cancer in a subject by inhibiting expression of PAX2. In the certain embodiments, the method of inhibiting...
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8080651 |
Juvenile hemochromatosis gene (HFE2A), expression products and uses thereof
Polynucleotide and polypeptide sequences for HFE2A, as well as mutations associated with juvenile hemochromatosis, and methods of utilizing these for the screening and identification of agents for...
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8080652 |
Gene silencing using mRNA-cDNA hybrids
The present invention provides novel compositions and methods for suppressing the expression of a targeted gene using mRNA-cDNA duplexes. The invention further provides novel methods and...
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8080531 |
Methods for modulating checkpoint activation through TopBP1
ATR kinase is a key regulator of checkpoint responses to incompletely replicated and damaged DNA. Without this checkpoint, cells will enter mitosis prematurely, likely resulting in cell death. The...
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